منابع مشابه
Comparative depression of several short acting barbiturates and spiro-barbiturates.
In an effort to develop new and possibly better types of barbiturates, suitable for intravenous use, a large number of spiro-barbiturates have been prepared by a ring closure on the 5-carbon atom of the barbituric acid and afforded for pharmacologic study. Spiro(2'-ethyl-3',5'-dimethyl cyclopentane) thio-barbituric acid appears to be the most promising product of a series of 50 analogues. Stoel...
متن کاملBarbiturates and oxidative phosphorylation.
It has been claimed that barbiturates uncouple oxidative phosphorylations (Brody & Bain, 1954; Brody, 1955). These authors have demonstrated that during the oxidation of pyruvate by liver and brain mitochondria, phosphate uptake was lowered proportionately more than oxygen uptake. Support for the uncoupling theory was derived from certain similarities between the barbiturates and 2:4dinitrophen...
متن کاملMechanism of action of barbiturates.
Despite the widespread use of barbiturates and their clear potential for abuse, little is known of their neurochemical mechanisms of action. Our purpose is to review the neurochemical effects of acute and chronic barbiturate administration, with particular emphasis on the relationship between neurochemical changes and the development of tolerance and dependence. The electrophysiological effects...
متن کاملGeneral Obstetrics and Gynecology: Obstetrics
Objective: We tested if fetal pulse oximetry in addition to electronic fetal monitoring (CTG) and scalp blood sampling improves the accuracy of fetal assessment and allows safe reduction of operative deliveries ( 50%) and scalp blood sampling ( 50%) performed because of nonreassuring fetal status. Study design: A randomized controlled trial was conducted in 146 patients with term pregnancies in...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1956
ISSN: 0007-0912
DOI: 10.1093/bja/28.6.257